Effect of Natural Biodegradable and Synthetic Polymer for Gastric Disease by Floating Microspheres

ABSTRACT The present study involves preparation and evaluation of floating microspheres with famotidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers acrycoat S100 and chitosan. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy, respectively. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Effects of natural biodegradable polymer chitosan and another acrycoat S 100 polymer on the size of microspheres, incorporation efficiency and in-vitro drug release were also observed. The prepared microspheres exhibited prolonged drug release more than 18 h, incorporation efficiency was change due to increase concentration of poly vinyl alcohol solution but remained buoyant for more than 12 h because clumping of polymers on surface of microspheres. The mean particle size increased and the drug release rate decreased at higher polymer concentration. In vitro studies demonstrated diffusion-controlled drug release from the prepared floating microspheres.